| INSTITUTION | DEGREE | DATES | FIELD |
| University of Michigan | B.S. | 1972 | Mathematics |
| Northern Illinois University | Ph.D. | 1987 | Chemistry |
| North Carolina State University | NIEHS Post-graduate Training Grant ES-07046 | 1987-1989 | Pharmacokinetics |
EXPERIENCE
1. 1972-1981: Software Engineer at the following facilities:
- Barber-Colman Co., Rockford, IL. Environmental control systems
- Martin-Marietta Aerospace Corp., Orlando, FL. Tactical weapons systems
- G+W Eagle Signal, Davenport, IA. Traffic control systems
- Dynalectron Corp., HAFB, NM. Radar signal analysis
2. 2/81-1/83 Scientific Software Consultant, Rockford, IL.
3. 1/83 - 5/87 Teaching/Research Assistant, Dept. of Chemistry, Northern Illinois University, Dekalb, IL.
4. 6/87-10/89 Postdoctoral Fellow, Toxicokinetics Laboratory, College of Veterinary Medicine, North Carolina State University, Box 8401, Raleigh, NC 27606.
5. 10/89-7/95 Research Assistant Professor of Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Box 8401, Raleigh, NC 27606.
6. 7/95-1/96 Research Associate Professor of Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Box 8401, Raleigh, NC 27606.
7. 1/96-present Adjunct Associate Professor of Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Box 8401, Raleigh, NC 27606.
8. 1/96 - present President, Polytheoretics, Inc., P.O. Box 1825, Wake Forest, NC 27588-1825.
GRANTS/CONTRACTS AWARDED
Co-Investigator:
USDA/FSIS-ES National Food Animal Residue Avoidance Databank (J.E. Riviere, P.I.)
- 91-EFSQ-1-4040 7/91 - 9/93 $122,500
- 93-EFSQ-1-4097 10/93 - 9/94 $ 82,500
- 94-EFSQ-1- 10/94 - 9/95 $157,500
BECTON DICKINSON
- The Isolated Perfused Porcine Skin Flap (IPPSF) as an In Vitro Model for Developing Drug Delivery Systems (J.E. Riviere, P.I.). 11/89 - 9/92 $1,500,773
PHS/NIH/NIEHS
- Mechanisms of Pesticide Toxicity: Project I: Pesticide Percutaneous Absorption, Metabolism and Toxicokinetics (J.E. Riviere, P.I.) P01-ES-00044. 7/88 - 2/93 $948,527
BATTELLE/MREF
- Isolated Perfused Porcine Skin Flap Transfer Project (J.E. Riviere, P.I.). 5/94 - 4/96 $391,759
GENSIA PHARMACEUTICALS
- Selected studies on transdermal iontophoretic drug delivery (J.E. Riviere, P.I.). 10/89 - 12/92 $216,911
EPA
- Quantitative prediction of xenobiotic percutaneous absorption and cutaneous disposition. (J.E. Riviere, P.I.) CR 818129. 10/91 - 2/93 $217,218
DoD/USAMRIDC
- Mechanism of Cutaneous Vesication (N. Monteiro,P.I.). DAMD-17-92C-2071 7/92 - 12/95 $862,377
NIH/NCI
- Hyperthermia and Perfusion Effects in Cancer Therapy (M.Dewhirst, P.I.). P01-CA-42745 6/90 - 5/93 $8,649,914
HONORS
The Ebert Prize, 1991; Established in 1873 by the American Pharmaceutical Association to honor "the best report of original investigation of a medical substance published in the Journal of Pharmaceutical Sciences in the past year." Awarded for manuscript describing the original IPPSF pharmacokinetic model.
TECHNOLOGY TRANSFER ACTIVITIES: Patents, Copyrights, and Licenses.
SOFTWARE COPYRIGHTS:
| Application | ID# | Date Registered | Platform | Description |
| Moments | TXu 622-548 | 11/18/93 | DEC/VMS | Statistical Moments |
| JiffyPlot | TXu 616-206 | 11/18/93 | DEC/VMS | Data Plotting |
| Iorama | TXu 622-559 | 11/18/93 | DEC/VMS | IPPSF Methodology (iontophoresis) |
| Invert | TXu 616-209 | 11/18/93 | DEC/VMS | Laplace solution inversion (kinetics) |
| V2V | TXu 622 549 | 11/18/93 | DEC/VMS | In vitro to in vivo kinetic modeling |
| DocuProg | TXu 616-208 | 11/18/93 | PC/Windows | Visual Basic program autodocumentation |
| Whole1 | TXu 622-555 | 11/18/93 | DEC/VMS | Assay recovery database |
| IPPSF Model | TXu 622-556 | 11/18/93 | DEC/VMS | IPPSF modeling package |
| Assimilate | TXu 616-935 | 11/18/93 | DEC/VMS | IPPSF Database |
| Roundup | TXu 622-557 | 11/18/93 | DEC/VMS | IPPSF Data reduction/analysis/plotting |
| Predict | TXu 622-412 | 11/18/93 | DEC/VMS | IPPSF Iontophoresis Modeling |
| Profile | TXu 616-936 | 11/18/93 | DEC/VMS | IPPSF Plotting |
| Species | NCSU#95-S8 | 4/25/95 | PC/Windows | Interspecies pharmacokinetics |
| Diffuse | NCSU#95-S7 | 4/25/95 | PC/Windows | Percutaneous diffusion simulation |
| BASICMan | NCSU#95-S9 | 4/25/95 | PC/Windows | Visual Basic module manager |
| Kinetica | NCSU#95-S10 | 4/25/95 | PC/Windows | General compartment model simulations |
| MDCMS | Applied | PC/Windows | Parallel nonlinear compartment models | |
| TrackVol | TXu 731-018 | 4/22/96 | PC/Windows | Volunteer Information System |
| RealCMA | TXu 734-482 | 4/22/96 | PC/Windows | Real Estate Comparative Market Analysis |
| Member$hip | TXu 733-665 | 4/22/96 | PC/Windows | Church Member Information System |
REGISTERED TRADEMARKS
PUBLICATIONS
1. Carver MP, Williams PL, Riviere JE: The isolated perfused porcine skin flap (IPPSF). III. Percutaneous absorption pharmacokinetics of organophosphates, steroids, benzoic acid and caffeine. Toxicol. Appl. Pharmacol. 97:324-337 (1989).
2. Williams PL, Fitch WM: Finding the minimal change in a given tree. In Hierarchy of Life, (Nobel symposium, Stockholm) Bremner BF, Journval H (Eds.). Elsevier, pp 453-470 (1989).
3. Williams PL, Riviere JE: Definition of a physiologic pharmacokinetic model of cutaneous drug disposition using the isolated perfused porcine skin flap (IPPSF). J. Pharm. Sci. 78:550-555 (1989).
4. Williams PL, Riviere JE: Physiological volume estimation in the isolated perfused porcine skin flap. Res. Comm. Chem. Pathol. Pharmacol. 66:145-158 (1989).
5. Williams PL, Fitch WM: Phylogeny determination using a dynamically-weighted parsimony method. In Methods in Enzymology, Vol. 183. Doolittle R, Ed., Academic Press, Orlando, FL pp 615-626 (1990).
6. Williams PL: Structural identifiability of pharmacokinetic models: compartments and experimental design. (Review). J. Vet. Pharmacol. Ther. 13:121-131 (1990).
7. Williams PL, Carver MP, Riviere JE: A physiologically relevant pharmacokinetic model of xenobiotic percutaneous absorption utilizing the isolated perfused porcine skin flap (IPPSF). J. Pharm. Sci. 79:305-311 (1990).
8. Williams PL, Riviere JE: Effect of hyperthermia on cisplatin (CDDP) disposition to isolated perfused skin. Int. J. Hyperthermia 6:923-932 (1990).
9. Hardie EM, Page RL, Williams PL, Fischer WD: The effect of time of administration on cisplatin toxicity and pharmacokinetics in dogs. Am. J. Vet. Res. 52:1821-1825 (1991).
10. Riviere JE, Page RL, Aucoin DP, Rogers RA, Williams PL: Effect of hyperthermia on the in vitro hydrolysis of melphalan. Int. J. Hyperthermia 7:527-529 (1991).
11. Riviere JE, Sage B., Williams PL: The effects of vasoactive drugs on transdermal lidocaine iontophoresis. J. Pharm. Sci. 80:615-620 (1991).
12. Riviere JE, Williams PL: On the Pharmacokinetic implications of changing blood flow in skin. J. Pharm. Sci. 81:601-602 (1992).
13. Riviere JE, Williams PL, Hillman RS, Mishky LM: Quantitative prediction of transdermal iontophoretic delivery of arbutamine in humans using the in vitro isolated perfused porcine skin flap (IPPSF). J. Pharm. Sci. 81:504-507 (1992).
14. Heit MC, Williams PL, Jayes FL, Chang SK, Riviere JE: Transdermal iontophoretic peptide delivery: in vitro and in vivo studies with leuteinizing hormone releasing hormone (LHRH). J. Pharm. Sci. 82:240-243 (1993).
15. Page RL, McEntee MC, George SL, Williams PL, Heidner GL, Novotney CA, Riviere JE, Dewhirst MW, Thrall DE: Pharmacokinetics and phase I evaluation of carboplatin in dogs with spontaneous tumors. J. Vet. Int. Med. 7:235-240 (1993).
16. Vaden SL, Williams PL, Page RL, Riviere JE: Effect of tumor presence on cisplatin and carboplatin disposition in the isolated perfused tumor and skin flap. Cancer Chemother. Pharmacol. 32:31-38 (1993).
17. Williams PL, Riviere JE: A model describing transdermal iontophoretic delivery of lidocaine incorporating consideration of cutaneous microvascular state. J. Pharm. Sci. 82:1080-1084 (1993).
18. Vaden SL, Page RL, Williams PL, Riviere JE: Effect of hyperthermia on cisplatin and carboplatin disposition in the isolated perfused porcine skin flap. Int. J. Hyperthermia 10:563-572 (1994).
19. Williams PL, Brooks JD, Inman AI, Monteiro-Riviere NA, Riviere JE: Determination of physiochemical properties of phenol, paranitrophenol, acetone and ethanol relevant to quantitating their percutaneous absorption in porcine skin. Res. Commun. Chem. Pathol. Pharmacol. 83:61-75 (1994).
20. Williams PL, Riviere JE: A "Full-Space" method for predicting in vivo transdermal plasma drug profiles reflecting both cutaneous and systemic variability. J. Pharm. Sci. 83:1062-1064 (1994).
21. Qiao GL, Williams PL, Riviere JE: Percutaneous absorption, biotransformation and systemic disposition of parathion In Vivo in swine. I. Comprehensive pharmacokinetic model. Drug Metab. Dispos. 22: 459-471 (1994).
22. Page RL, McEntee MC, Williams PL, George SL, Price GS, Novotney CA, Hauck ML, Riviere JE, Dewhirst MW, Thrall DE: Effect of whole body hyperthermia on carboplatin disposition and toxicity in dogs. Int. J. Hyperthermia 10:807-816 (1994).
23. Chang SK, Williams PL, Dauterman WC, Riviere JE: Percutaneous absorption, dermatopharmacokinetics, and related biotransformation studies of carbaryl, lindane, malathion and parathion in isolated perfused porcine skin. Toxicology 91:269-280 (1994).
24. Riviere JE, Monteiro-Riviere NA, Williams PL: Isolated perfused porcine skin flap as an In Vitro model for predicting transdermal pharmacokinetics. Eur. J. Pharm. Biopharm. 41:152-162 (1995).
25. Williams PL, Riviere JE: A biophysically-based dermatopharmacokinetic compartment model for quantifying percutaneous penetration and absorption of topically-applied agents. I. Theory. J. Pharm. Sci. 84:599-608 (1995).
26. Riviere JE, Brooks JD, Williams PL, Monteiro-Riviere NA: Toxicokinetics of topical sulfur mustard penetration, disposition, and vascular toxicity in isolated perfused porcine skin. Toxicol. Appl. Pharmacol. 135:25-34 (1995).
27. Riviere JE, Brooks JD, Williams PL, McGown E, Francoeur ML: Cutaneous metabolism of isosorbide dinitrate after transdermal administration in isolated perfused porcine skin. Int. J. Pharm. 127:213-217 (1996).
28. Qiao, G.L.; Brooks, J.D.; Baynes, R.E.; Monteiro-Riviere, N.A.; Williams, P.L.; Riviere, J.E.: The Use of Mechanistically-Defined Chemical Mixtures (MDCM) to Assess Mixture Component Effects on the Percutaneous Absorption and Cutaneous Disposition of Topically-Exposed Chemicals. I. Studies with parathion mixtures in isolated perfused porcine skin. Toxicol. Appl. Pharmacol. 141:473-486 (1996).
29. Williams, P.L.; Thompson, D.; Qiao, G.L.; Monteiro-Riviere, N.A.; Baynes, R.E.; Riviere, J.E.: The Use of Mechanistically-Defined Chemical Mixtures (MDCM) to Assess Mixture Component Effects on the Percutaneous Absorption and Cutaneous Disposition of Topically-Exposed Chemicals. II. Development of a General Dermatopharmacokinetic Model for Use in Risk Assessment. Toxicol. Appl. Pharmacol. 141:487-496 (1996).
PUBLICATIONS: ABSTRACTS AND LETTERS
1. Williams PL: Reversible evolution? Nature 328:21 (1987).
2. Riviere JE, Williams PL: Interaction of regional hyperthermia with antineoplastic drug delivery pharmacokinetics. Studies in an isolated perfused skin flap system. Proc. Rad. Res. Soc. 36:16 (1988).
3. Williams PL, Carver MP, Riviere JE: Pharmacokinetic models of xenobiotic disposition in skin. North Carolina Society of Toxicology Symposium, Research Triangle Park, NC (1988).
4. Williams PL, Carver MP, Riviere JE: Mathematical modeling of xenobiotics pharmacokinetics and disposition in skin. Symposium of the North Carolina State University Toxicology Program, Raleigh, NC (1988).
5. Williams PL, Riviere JE: A pharmacokinetic model describing xenobiotic percutaneous absorption in the isolated perfused porcine skin flap. Second Symposium on Frontiers of Pharmacokinetics and Pharmacodynamics (1988).
6. Riviere JE, Williams PL: Quantitative prediction of in vivo percutaneous absorption profiles using in vitro perfused porcine skin. Toxicologist 9:60 (1989).
7. Chang SK, Williams PL, Riviere JE: Percutaneous absorption of radiolabeled organophosphates, carbaryl and lindane in the isolated perfused porcine skin flap. Toxicologist 10:257 (1990).
8. Chang SK, Monteiro-Riviere NA, Williams PL, King JR, Riviere JE: The isolated perfused porcine skin flap (IPPSF). A new model for the study of percutaneous absorption and cutaneous toxicity. Proc. 2nd Int. Symp. on Pig Model Biomedical Res. (1990).
9. Page RL, Thrall DE, Riviere JE, Williams PL, Lee GJ, Dewhirst MW: Effect of anesthesia and whole body hyperthermia (WBH) on cisplatin (CDDP) and carboplatin (CBDCA) tissue distribution. Proc. 9th Int. Congr. Rad. Res. (1990).
10. Hauck ML, Novotney CA, McEntee MC, Ogilvie GK, Williams PL, Cacek T, Page RL: Toxicity, pharmacokinetics and efficacy of mitoxantrone administered as a 1-hour infusion in dogs with lymphoma. 11th Annual Conference of VCS (1991).
11. Vaden SL, Williams PL, Riviere JE: Cisplatin uptake in the isolated and perfused tumor and skin flap. Annual Phi Zeta Research Forum, Raleigh, NC (1991).
12. Williams PL, Riviere JE: A pharmacokinetic model describing iontophoretic drug delivery and subsequent disposition of lidocaine in the isolated perfused porcine skin flap (IPPSF). Pharm. Res. 8:S292 (1991).
13. Vaden SL, Williams PL, Page RL, Riviere JE: The effects of hyperthermia and tumor presence on cisplatin uptake in an isolated, perfused tumor and skin flap. Proc. Am. Assoc. Cancer Res. 33:531 (1992).
14. Heit MC, Williams PL, Jayes FL, Chang SK, Riviere JE: Predictions of the in vivo transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) based on in vitro flux. Pharm. Res. 9:S191 (1992).
15. Riviere JE, Qiao G, Chang SK,Williams PL: Comprehensive pharmacokinetic model of topical parathion percutaneous absorption, systemic disposition and biotransformation integrating in vivo, in vitro diffusion cell, and isolated perfused porcine skin flap (IPPSF) data. Toxicologist 13:50 (1993).
16. Arenson DR, Sonne K, Williams PL, Hillman RS, Riviere JE: Comparison of various models for predicting iontophoresis of arbutamine through human skin. Proc. Int. Symp. Control. Rel. Bioact. Mater. 20 (1993).
17. Qiao GL, Chang SK, Williams PL, Brooks JD, Riviere JE: Percutaneous absorption, biotransformation, and systemic disposition of topical parathion in vivo in swine. Development of a comprehensive pharmacokinetic model. Pharm. Res. 10: S251 (1993).
18. Williams PL, Brooks JD, Riviere JE: A biophysically based pharmacokinetic model of percutaneous penetration and absorption. Pharm. Res 10: S251 (1993).
19. Qiao GL, Chang SK, Williams PL, Brooks JD, Riviere JE: Comprehensive pharmacokinetic model of parathion percutaneous absorption, biotransformation and systemic disposition in vivo in swine. North Carolina State University College of Veterinary Medicine Annual Forum, Raleigh, NC (1993).
20. Williams PL, Brooks JD, Riviere JE: A biophysically-based pharmacokinetic model of percutaneous penetration and absorption. Biological Mechanisms and Quantitative Risk Assessment: Health Effects Research Laboratory Symposium, Research Triangle Park, NC (1993).
21. Williams PL, Brooks JD, Inman AO, Monteiro-Riviere NA, Riviere JE: A biophysically-based pharmacokinetic model of percutaneous penetration and absorption. Annual Meeting of the American Association of Pharmaceutical Scientists, Orlando, FL (1993).
22. Riviere JE, Williams PL, Zhang Z, Monteiro-Riviere NA: Toxicokinetics of sulfur mustard cutaneous disposition and percutaneous absorption in isolated perfused porcine skin. Toxicologist 14: 184 (1994).
23. Monteiro-Riviere NA, Zhang Z, Williams PL, Riviere JE: Sulfur mustard causes vascular and inflammatory changes in isolated perfused porcine skin. Toxicologist 14: 104 (1994).
24. Riviere JE, Brooks JD, Williams PL, McGowan E, Francoeur ML: Cutaneous metabolism of isosorbide dinitrate after transdermal administration. Pharm. Res. 11: S190 (1994).
25.. Baynes RE, Qiao GL, Brooks JD, Monteiro-Riviere NA, Williams PL, Riviere JE: An experimental design for assessing percutaneous absorption of chemical mixtures in isolated perfused porcine skin flaps. Proc. Symp. Chemical Mixtures and Quantitative Riosk Assessment, Research Triangle Park, NC, Nov. (1994).
26. Qiao GL, Baynes R, Brooks JD, Monteiro-Riviere NA, Williams PL, Riviere JE: Interactions in the percutaneous absorption and cutaneous disposition of parathion applied as a chemical mixture in isolated perfused porcine skin flaps. Proc. Symp. Chemical Mixtures and Quantitative Risk Assessment, Research Triangle Park, NC, Nov.1994.
27. Riviere JE, Williams PL, Monteiro-Riviere NA: Mechanistically defined chemical mixtures (MDCM): A new experimental paradigm for risk assessment applied to skin. Toxicologist 15:323 (1995).
28. Williams PL, Brooks JD, Monteiro-Riviere NA, Riviere JE: Quantitative percutaneous absorption and distribution of binary mixtures of two phenols in the isolated perfused porcine skin flap. Toxicologist 15:328 (1995).
29. Smith CE, Williams PL, Riviere JE: Compartment models of skin transport: dominant eigenvalues approach. Proc. Biometrics Sec., Am. Statis. Assoc., Washington, DC, pgs 449-454 (1995).
INVITED PRESENTATIONS
Toward a more general quantitative model for percutaneous absorption. USAF Skin Workshop, Wright-Patterson AFB, OH, 7/19-7/20 (1994).